Mark Isham (born September 7, 1951) is an American trumpeter, synthesist, and composer. He works in a variety of genres, including jazz, electronic, and film.

Isham was born in New York City. He studied classical music at an early age and played trumpet, piano and violin. The Isham family later moved to San Francisco, where Mark found work in several of the local orchestras. He also became actively involved in the Bay Area rock and roll scene of the 1960s, performing live with several of the local groups.

He became a member of a group called Beefy Red. In 1966 Isham and several other members of Beefy Red joined the newly formed band The Sons of Champlin. The Sons of Champlin were unique to the San Francisco psychedelic scene in featuring a large brass section.

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