Gagliano is the surname of:

• Alfonso Gagliano (born 1942), a Canadian Liberal Party politician, Quebec MP, Canadian Labour Minister, and Deputy House Leader.
• Bob Gagliano, a professional American football player (quarterback).
• Ted Gagliano, film post production executive (Indiana Jones and the Temple of Doom, the Star Wars trilogy, Titanic).
• Christophe Gagliano, a French athlete (Olympic judo champion).
• Frank Gagliano, a playwright from West Virginia University.
• Joseph Gagliano (1914-1971), a member of the Chicago Outfit crime syndicate.
• Marco da Gagliano (1582-1643), an Italian composer.
• Nicolò Gagliano (1740-1780), an Italian violin maker.
• Phil Gagliano, a major league baseball player (St Louis Cardinals, etc.).
• Pietro Gagliano (born 1979), Canadian graphic designer.
• Ralph Gagliano, a major league baseball player.
• Gaetano Gagliano (see Tommy Gagliano), an Italian-American Depression-era Godfather in the New York Mafia (1931 to 1953).
• Professor Sam Gagliano (1907-1993), pianist and American music teacher, trained in Rome at the noted Royal Conservatory of Music.
• Dr. Sherwood Gagliano (1939?- ), "father of the Louisiana coastal restoration movement" and consulting geological scientist.