Panozzo grew up in the Pullman district, the south side of Chicago, Illinois with his twin brother, Chuck (born 90 minutes apart). At age 7, the twins took musical lessons from their uncle in which John took an interest in drums and percussion. They attended Catholic school and eventually they were part of a 25-piece accordian band in which John played drums and Chuck played guitar. They would play weddings at age 12 and were paid $15 a piece.
Then, in 1961, John, Chuck, and their neighbor, Dennis DeYoung, formed a band called the Tradewinds in which John played drums, Chuck played guitar, and Dennis played the accordion and sang. They played local rock and roll gigs at bars and began gaining popularity as a garage band on the south side. In 1970, Chuck switched to bass and they added guitarists/vocalists James "J.Y." Young and John Curulewski, changing their name to TW4. The band signed to Wooden Nickel Records and changed their name to Styx. The rest is history.
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